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Kidney/liver illness. You may need a decreased dose When you've got problems with your kidneys or liver simply because All those circumstances enable it to be more difficult for your body to crystal clear the drug.Having hydrocodone or oxycodone with antidepressants can lead to a hazardous buildup of your brain chemical serotonin.Normalt sett finns
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Omtrent 7-9 % af den kaukasiske befolkning har variationer i CYP2D6 genet som koder for ingen- eller nedsat aktivitet af CYP2D6 (se personlig medicin ). Tramadol et produg der omdannes til den aktive metabolit by means of CYP2D6. Patienter med nedsat eller manglende aktivitet af CYP2D6, vil have reduceret- eller manglende effekt af tramadol.Patient